May anaphylaxis include?

• A. Sneezing and runny nose
• B. Headache only
• C. Stomach ache
• D. Hives and difficulty breathing.

Answer: (D)

Anaphylaxis is a rapid, life-threatening allergic reaction that involves multiple body systems. The clearest signs are skin symptoms like hives together with breathing problems such as trouble breathing or wheezing. This combination shows systemic involvement and requires immediate medical attention. Sneezing and runny nose are common with allergic rhinitis, not a dangerous reaction; headache alone is nonspecific; stomach ache can occur but isn’t the defining sign of anaphylaxis. Therefore, hives and difficulty breathing best indicate anaphylaxis and signal an emergency response, including seeking help immediately and using epinephrine if available.